Tokyo University of Pharmacy and Life Sciences. Laboratory of Genome and Biosignals
1432-1 Horinouchi, Hachioji-city, Tokyo 192-0392, Japan
Tel: +81-42-676-7221／Fax: +81-42-676-7249
略歴
2001年 3月
東京理科大学理工学部卒業
2003年 3月
東京大学理学系研究科修士課程卒業
2003年 - 2006年
日本学術振興会特別研究員(DC1)
2006年 3月
東京大学理学系研究科博士課程卒業
2006年 - 2010年
国立がん研究センター研究所
2010年 4月 - 12月
日本学術振興会特別研究員(PD)
2011年1月 -2019年3月
東京薬科大学生命科学部ゲノム情報学研究室助教
2019年4月 -
東京薬科大学生命科学部ゲノム病態医科学研究室講師
現在に至る
所属学会
日本癌学会、生化学会
受賞歴
2016年度
水島昭二記念研究賞
2017年度
第76回日本癌学会学術総会 WSCRシンポジウム賞
2018年度
日本生化学会奨励賞
2018年度
日本癌学会奨励賞
研究概要
がん細胞における薬剤耐性機構の解明と創薬シーズの探索
主な研究業績
＜英文原著論文＞
Kudo, K., Yoneda, A., Sakiyam,a D., Kojima, K., Miyaji, T., Yamazaki, M., Yaita, S., Hyodo, T., Satow, R., Fukami, K. Cell surface CD63 increased by up-regulated polylactosamine modification sensitizes human melanoma cells to the BRAF inhibitor PLX4032. FASEB J. fj201800664RR (2018).
Satow,R.,Inagaki, S., Kato, C., Shimozawa, M., Fukami, Identification of zinc finger protein of the cerebellum 5 as a survival factor of prostate and colorectal cancer cells. Cancer Sci. 108(12), 2405-2412 (2017).
Shimozaw, M., Anzai, S., Satow,R, Fukami, K. Phospholipase C δ1 negatively regulates autophagy in colorectal cancer cells. Biochem. Biochem. Biophys. Res. Commun. 488(4), 578-583 (2017).
Satow,R., Nakamura,T., Kato,C., Endo,M., Tamura,M., Batori,R., Tomura,S., Murayama,Y., Fukami,K. ZIC5 drives melanoma aggressiveness by PDGFD-mediated activation of FAK and STAT3. Cancer Res. 77.366-377 (2017)
Satow, R., Hirano, T., Batori, R,, Nakamura, T., Murayama, Y., and Fukami, K. Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells. Proc. Natl. Acad. Sci. USA 111, 13505-10 (2014)
Kobayashi, E., Satow, R., Ono., M, Masuda, M., Honda, K., Sakuma, T., Kawai, A., Morioka, H., Toyama, Y., and Yamada, T. MicroRNA expression and functional profiles of osteosarcoma. Oncology. 86, 94-103 (2014)
*Hirano, T., *Satow, R., Kato, A., Tamura, M., Murayama, Y., Saya, H., Kojima, H., Nagano, T., Okabe, T., and Fukami, K. Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness. Biochem. Pharmacol. 86, 1419-29 (2013). (*equal contribution)
Satow, R., Shitashige, M., Jigami, T., Fukami, K., Honda, K., Kitabayashi, I., and Yamada, T. β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. Gastroenterology 142, 572-81 (2012)
Hirata, M,. Suzuki, M., Ishii, R., Satow, R., Uchida, T., Kitazumi ,T., Sasaki, T., Kitamura, T., Yamaguchi, H., Nakamura, Y., and Fukami, K. Genetic defect in Phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis. Diabetes. 60, 1926-37 (2011)
Ito, H., Honda, K., Satow, R., Arai, E., Shitashige, M., Ono, M., Sakuma, T., Sakano, S., Naito, K., Matsuyama, H., and Yamada, T. Combined functional genome survey of therapeutic targets for clear cell carcinoma of the kidney. Jpn. J. Clin. Oncol. 41, 847-53 (2011)
Satow, R., Shitashige, M., Jigami, T., Honda, K., Ono, M., Hirohashi, S., and Yamada, T. Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation. J. Biol. Chem. 285, 26289-94 (2010)
Shitashige, M., Satow, R., Jigami, T., Aoki, K,. Honda, K., Shibata, T., Ono, M., Hirohashi, S., and Yamada, T. Traf2- and Nck-interacting kinase TNIK is essential for Wnt signaling and colorectal cancer growth. Cancer Res. 70, 5024-33 (2010)
Satow, R., Shitashige, M., Kanai, Y., Takeshita, F., Ojima, H., Jigami, T., Honda, K., Kosuge, T., Ochiya, T., Hirohashi, S., and Yamada, T. Combined functional genome survey of therapeutic targets for hepatocellular carcinoma. Clin. Cancer Res. 16. 2518-28 (2010)
Kobayashi, E., Masuda, M., Nakayama, R., Ichikawa, H., Satow, R., Shitashige, M., Honda, K., Yamaguchi, U., Shoji, A., Tochigi, N., Morioka, H., Toyama, Y., Hirohashi, S., Kawai, A., and Yamada, T. Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma. Mol. Cancer Ther. 9, 535-44 (2010)
Yamaguchi, U., Honda, K., Satow, R., Kobayashi, E., Nakayama, R., Ichikawa, H., Shoji, A., Shitashige, M., Masuda, M., Kawai, A., Chuman, H., Iwamoto, Y., Hirohashi, S., and Yamada, T. Functional genome screen for therapeutic targets of osteosarcoma. Cancer Sci. 100, 2268-74 (2009)
Negishi, A., Masuda, M., Ono, M., Honda, K., Shitashige, M., Satow, R., Sakuma, T., Kuwabara, H., Nakanishi, Y., Kanai, Y., Omura, K., Hirohashi, S., and Yamada, T. Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma. Cancer Sci. 100, 1605-11 (2009)
Negishi , A., Ono, M., Handa, Y., Kato, H., Yamashita, K., Honda, K., Shitashige, M., Satow R, Sakuma, T., Kuwabara, H., Omura, K., Hirohashi, S., and Yamada, T. Large-scale quantitative clinical proteomics by label-free liquid chromatography and mass spectrometry. Cancer Sci. 100, 514-519 (2009)
Shitashige, M., Satow, R., Honda, K., Ono, M., Hirohashi, S., and Yamada, T. ,Regulation of Wnt signaling by the nuclear pore complex. Gastroenterology 134, 1961-1971 (2008)
Huang, L., Shitashige, M., Satow, R., Honda, K., Ono, M., Yun, J., Tomida, A., Tsuruo, T., Hirohashi, S., Yamada, T. Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex. Gastroenterology 133, 1569-78 (2007)
Shitashige, M., Satow, R., Honda, K., Ono, M., Hirohashi, S., and Yamada, T. Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis. Cancer Sci. 98, 1862-1867 (2007)
Satow, R., Kurisaki, A., Chan, TC., Hamazaki, TS., and Asashima, M. Dullard Promotes Degradation and Dephosphorylation of BMP Receptors and Is Required for Neural Induction. Dev. Cell. 11, 763-74 (2006)
Chan, TC., Satow, R., Kitagawa, H., Kato, S., and Asashima, M. Ledgerline, a Novel Xenopus laevis Gene, Regulates Differentiation of Presomitic Mesoderm During Somitogenesis. Zool. Sci. 23, 689-697 (2006)
Li, DH., Chan, TC., Satow, R., Komazaki, S., Hashizume, K., and Asashima, M. The role of XTRAP-gamma in Xenopus pronephros development. Int. J. Dev. Biol. 49. 401-408 (2005)
Satow, R., Chan, TC., and Asashima, M. The role of Xenopus frizzled-8 in pronephric development. Biochem. Biophys. Res. Commun. 321, 487-494 (2004)
Kaneko, T., Chan, TC., Satow, R., Fujita, T., and Asashima M. The isolation and characterization of XC3H-3b: a CCCH zinc-finger protein required for pronephros development. Biochem. Biophys. Res. Commun. 308, 566-572 (2003)
Satow, R., Chan, TC., and Asashima M. Molecular cloning and characteriztion of Dullard : a novel gene required for neural development. Biochem. Biophys. Res. Commun. 295. 85-91 (2002)
